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Ricardo Maldini

Resumen biográfico The activity of genes that cause autoimmune diseases or allergies in the event of a malfunction can be determined on a large scale using so-called DNA chips. Scientists from the Society for Biotechnological Research (GBF) seborrheic dermatitis and hair loss are using this technique in the hope of obtaining evidence of new therapies against diseases in which the immune system attacks their own bodies.

If a person has infected with viruses or bacteria, his immune system defends him. T cells are used. In them, a variety of genes must be switched on and off at the right time, so that the defense is successful. If the interactions of these genes are disturbed, the T cells may turn against not only the pathogens, but also against body-specific proteins: autoimmune disease occurs.

The identification of the involved genes is made possible by DNA chip technology. Using this modern method, the activity of up to 12,000 genes can be determined simultaneously. The scientists worked with extracts from T cells. By comparing healthy and malformed T cells, we can then identify those genes that are important for seborrheic keratosis treatment the course of the disease. In the long term, the scientists hope to develop new drugs for diseases such as psoriasis, diabetes, multiple sclerosis, rheumatoid arthritis or asthma.

Around 2.2 million people are suffering from psoriasis. In the research of this so-called psoriasis, new approaches to immunological causes of disease point out. This was communicated at the meeting of the German Dermatological Society in Berlin.

"It has been found that most of the inflammatory reactions of the skin are caused by itching, redness, scaling and oozing by the defense cells activated in the skin," explained Professor Enno Christophers of the dermatology clinic of the University of Kiel. These so-called lymphocytes or T-cells actually serve the specific defense against pathogens. In autoimmune diseases such as psoriasis, the attacks of lymphocytes can also be directed against corporeal cells.

This finding leads to completely new approaches for the therapy of psoriasis. In new studies, the patient is injected with  seborrheic dermatitis and hair loss antibodies or fusion products that directly attach to certain proteins on the surface of the T cell or their messenger substances and thereby destroy them. According to Christophers, these studies are very successful.